01What it is

Praxiom integrates an Oral Health Score — built from salivary biomarkers including aMMP-8, IL-1β, IL-8 and oral microbiome composition — alongside the systemic, cardiovascular and fitness domains already used in longevity care, into a single Personal Health Index with a derived biological-age estimate.

The method is covered by US Provisional Patent 64/037,261 and is implemented in an iOS application available in English and Arabic, with an AI lab-report scanner that reads biomarker values from test reports in any language.

What the clinician receives. Praxiom Life produces a doctor-ready report: graded Tier 1–3 biomarker tables, flagged values, age-expected reference values printed beside the patient’s own, wearable-derived physiology, trend analysis across assessments, and per-patient findings computed from repeat measurements. Clinicians who run these tests can be listed in the app’s Doctor Connect directory — write to doctors@praxiom.life.

Where it sits in longevity practice. The framework follows the model of Abu Dhabi’s Healthy Longevity Medicine Clinic Standard (Department of Health, issued October 2024, in force April 2025): molecular, physiological and digital markers of ageing, with repeat testing to confirm that a plan is working, read here against the patient’s own baseline rather than a population cut-off alone. That standard does not name oral health; the oral–systemic axis is the domain Praxiom adds. The founder is a member of the Healthy Longevity Medicine Society; the framework itself is independent of the Society and carries no endorsement.

02Why it matters clinically

• Cardiovascular: Salivary active MMP-8 is a chairside marker of active periodontal breakdown (Lähteenmäki et al., Diagnostics 2020); periodontitis is independently associated with cardiovascular disease (Sanz et al., J Clin Periodontol 2020, consensus report); and P. gingivalis translocating to the atria drives atrial fibrosis and fibrillation in a mouse model with matching human atrial samples (Miyauchi et al., Circulation 2025).
• Neurodegenerative: Subgingival microbiota composition is associated with cognitive performance, inflammation and brain structure (cortical thickness, subcortical volume) in 1,026 adults of the Hamburg PAROMIND study (Petersen et al., EBioMedicine 2026).
• Metabolic & inflammaging: Periodontal therapy lowers systemic hs-CRP: weighted mean difference −0.50 mg/L across 25 trials (Teeuw et al., J Clin Periodontol 2014, meta-analysis), sustained at 9–12 months in metabolic syndrome (López et al., J Periodontol 2012) — the oral cavity is a modifiable intervention site, not just a marker.
• Foundational to the field: the Dunedin Study’s “Pace of Aging,” the basis for the DunedinPACE epigenetic clock, tracks decline across 19 biomarkers spanning the cardiovascular, metabolic, renal, immune, dental and pulmonary systems (Elliott et al., Nature Aging 2021; method introduced in Belsky et al., PNAS 2015).

03The validation protocol

A pre-specified prospective protocol, ready for OSF / ClinicalTrials.gov registration, implementable by any longevity clinic with saliva collection and standard blood panels.

The framework is in active development. Individual biomarkers are supported by published evidence; the composite has not yet been externally validated. The enrolment target of 280–320 participants is the overall goal and is meant to be shared across participating clinics and cohorts. The founder’s Munich practice contributes a cohort of 60 patients, followed over 18 months, with ethics submission pending. The six-month protocol above is the template offered to other clinics and cohorts as participating sites; it is designed to provide the first external validation, and is an open invitation to collaborate.

04Who’s behind it

Dr. med. stom Costin Marinescu, D.D.S. — specialist in advanced restorative and preventive dentistry, Munich. Founder of Praxiom Life 2.0. Member, Healthy Longevity Medicine Society.

Dr. med. Nike Arnstadt — a medical doctor specialized in functional medicine.

Praxiom is built by practicing clinicians who see the oral–systemic connection in patients every day — not a software company looking for a medical use case.