{"id":36,"date":"2026-04-18T18:18:43","date_gmt":"2026-04-18T18:18:43","guid":{"rendered":"https:\/\/praxiom.life\/?page_id=36"},"modified":"2026-04-18T18:18:43","modified_gmt":"2026-04-18T18:18:43","slug":"science-research","status":"publish","type":"page","link":"https:\/\/praxiom.life\/?page_id=36","title":{"rendered":"Science &amp; Research"},"content":{"rendered":"\n<p>Praxiom Life is built on a simple idea: biological age is measurable, modifiable, and shows up early in the mouth, the blood, and daily function\u2014not just in how many birthdays you have had. Our Bio\u2011Age engine translates cutting\u2011edge biomarker and aging\u2011clock research into a single, clinically usable score for patients and clinicians.\u200b<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"1-multisystem-view-of-biological-age\">1. Multi\u2011System View of Biological Age<\/h2>\n\n\n\n<p>Modern aging science has moved beyond single markers to composite \u201cclocks\u201d that integrate information across many systems. Large plasma proteomics studies have created organ\u2011specific and whole\u2011body aging clocks that outperform traditional risk factors in predicting mortality and disease. Next\u2011generation DNA methylation clocks do the same at the epigenetic level, capturing cell\u2011level aging processes across 11 physiological systems from a single blood test.\u200b<\/p>\n\n\n\n<p>Key references (examples):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Proteomic aging clocks and organ\u2011specific aging models (Cell Metabolism 2025, PLoS Medicine 2024, npj Aging 2025).\u200b<\/li>\n\n\n\n<li>Systems\u2011level epigenetic clocks such as Systems Age and DunedinPACE (Nature Aging 2025, Alzheimer\u2019s &amp; Dementia 2024).\u200b<\/li>\n\n\n\n<li>Telomere length and epigenetic age acceleration as independent predictors of mortality and stroke risk (Aging Cell 2025, Journal of Stroke &amp; Cerebrovascular Diseases 2026).\u200b<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"2-biomarkers-that-matter-for-longevity\">2. Biomarkers That Matter for Longevity<\/h2>\n\n\n\n<p>Praxiom Life\u2019s framework is anchored in biomarker domains repeatedly linked to healthspan, frailty, and mortality.\u200b<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Inflammation &amp; \u201cinflammageing\u201d<\/strong><br>IL\u20116, hs\u2011CRP, GDF\u201115, CXCL9 and composite inflammation scores robustly predict frailty, cognitive decline, and mortality. Systematic reviews confirm IL\u20116 as a core inflammaging biomarker in community\u2011dwelling adults.\u200b<\/li>\n\n\n\n<li><strong>Metabolic and glycemic health<\/strong><br>HbA1c alone misses key aging signals; continuous glucose metrics like Time\u2011in\u2011Range and glycemic variability correlate with cellular senescence, oxidative stress, and cognitive decline. Metabolomic age scores (e.g., MileAge) further capture aging\u2011related metabolic patterns beyond single markers.\u200b<\/li>\n\n\n\n<li><strong>Proteins and hormones of aging<\/strong><br>GDF\u201115, FGF\u201121, NAD\u2011related pathways, IGF\u20111, and plasma proteomic indices track systemic stress, metabolic flexibility, and longevity across large cohorts. Human GDF\u201115 \u201cknockout\u201d data refine what truly healthy ranges look like for long\u2011term health.\u200b<\/li>\n\n\n\n<li><strong>Telomeres and epigenetic clocks<\/strong><br>Telomere length and advanced DNA\u2011methylation clocks provide complementary views of biological aging and are consistently associated with mortality and age\u2011related disease.\u200b<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"3-oral-and-microbiome-signals\">3. Oral and Microbiome Signals<\/h2>\n\n\n\n<p>Praxiom Life adds something traditional longevity platforms miss: an explicit <strong>oral and microbiome<\/strong>&nbsp;dimension.\u200b<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chronic periodontitis drives systemic inflammation and is linked to neurodegeneration, cognitive decline, and frailty in older adults.\u200b<\/li>\n\n\n\n<li>Oral and salivary microbiome diversity changes with age and correlates with systemic cytokines and aging phenotypes, making it a practical early biomarker of biological aging.\u200b<\/li>\n\n\n\n<li>Gut microbiome diversity and composition are repeatedly associated with healthy longevity, metabolic health, and inflammaging.\u200b<\/li>\n<\/ul>\n\n\n\n<p>Recent work in elderly cohorts shows that shifts in oral and gut microbial diversity track with systemic fatty acids, inflammatory markers, and age\u2011related disease risk.\u200b<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"4-function-and-realworld-aging\">4. Function and \u201cReal\u2011World\u201d Aging<\/h2>\n\n\n\n<p>Biological age is not only molecular\u2014it is visible in&nbsp;<strong>how people move and function<\/strong>.\u200b<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Handgrip strength and gait speed are among the most robust predictors of mortality, frailty, heart failure outcomes, and \u201cexceptional ager\u201d phenotypes.\u200b<\/li>\n\n\n\n<li>Allostatic load indices and sleep\u2011inflammation studies show that chronic stress and poor sleep translate into accelerated brain and white\u2011matter aging.\u200b<\/li>\n<\/ul>\n\n\n\n<p>Praxiom incorporates these functional and stress\u2011load concepts as part of a practical, clinic\u2011friendly view of aging rather than treating them as separate from lab values.\u200b<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"5-how-praxiom-uses-this-science\">5. How Praxiom Uses This Science<\/h2>\n\n\n\n<p>Praxiom does not simply copy a single academic clock; it&nbsp;<strong>integrates<\/strong>&nbsp;these validated domains into a pragmatic scoring model.\u200b<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>We start from high\u2011grade evidence (systematic reviews, large cohorts, Mendelian randomization) to assign weights to biomarker families\u2014oral inflammation, systemic inflammation, glucose dynamics, proteomics, epigenetics, functional status, and stress load.\u200b<\/li>\n\n\n\n<li>The algorithm favors\u00a0<strong>multi\u2011marker patterns<\/strong>\u00a0(e.g., IL\u20116 + CRP + GDF\u201115; HbA1c + CGM variability; periodontal status + pathogen load + oral microbiome diversity) rather than single cut\u2011offs, reflecting how modern clocks work.\u200b<\/li>\n\n\n\n<li>Over time, longitudinal data (how your profile changes) is treated as more important than any single snapshot.\u200b<\/li>\n<\/ul>\n\n\n\n<p>Praxiom Life\u2019s Bio\u2011Age score is therefore best thought of as a <strong>translational layer<\/strong>: it brings state\u2011of\u2011the\u2011art aging science into a form that dentists, physicians, and patients can understand and act on visit by visit.<\/p>\n\n\n\n<p>PubMed links that inform the Praxiom model:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Inflammaging biomarkers and clinical outcomes (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40562315\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ageing Research Reviews 2025; PubMed 40562315<\/a>).\u200b<\/li>\n\n\n\n<li>NAD and aging (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41655607\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ageing Research Reviews 2026; PubMed 41655607<\/a>).\u200b<\/li>\n\n\n\n<li>Proteomic aging clocks (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39488213\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cell Metabolism 2025; PubMed 39488213<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39316596\/\" target=\"_blank\" rel=\"noreferrer noopener\">PLoS Medicine 2024; PubMed 39316596<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40287427\/\" target=\"_blank\" rel=\"noreferrer noopener\">npj Aging 2025; PubMed 40287427<\/a>).\u200b<\/li>\n\n\n\n<li>Systems Age epigenetic clock (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40954326\/\" target=\"_blank\" rel=\"noreferrer noopener\">Nature Aging 2025; PubMed 40954326<\/a>).\u200b<\/li>\n\n\n\n<li>Telomere length, epigenetic age, and mortality (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40619637\/\" target=\"_blank\" rel=\"noreferrer noopener\">Aging Cell 2025; PubMed 40619637<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41407084\/\">Journal of Stroke &amp; Cerebrovascular Diseases 2026; PubMed 41407084<\/a>).\u200b<\/li>\n\n\n\n<li>Gut and oral microbiome diversity and longevity (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39110402\/\" target=\"_blank\" rel=\"noreferrer noopener\">Science China Life Sciences 2024; PubMed 39110402<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41592670\/\" target=\"_blank\" rel=\"noreferrer noopener\">Experimental Gerontology 2026; PubMed 41592670<\/a>; <a href=\"https:\/\/europepmc.org\/article\/med\/27383981\" target=\"_blank\" rel=\"noreferrer noopener\">Nutrition Reviews 2025<\/a>).\u200b<\/li>\n\n\n\n<li>Chronic periodontitis, systemic inflammation, and neurodegeneration (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41612446\/\" target=\"_blank\" rel=\"noreferrer noopener\">Journal of Neuroinflammation 2026; PubMed 41612446<\/a>).\u200b<\/li>\n\n\n\n<li>Grip strength, gait speed, and mortality (multiple cohort studies across BMC Geriatrics 2025, GeroScience 2026, J Am Heart Assoc 2026, J Gerontol A 2025; see report for PubMed IDs <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40993531\/\" target=\"_blank\" rel=\"noreferrer noopener\">40993531<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40889076\/\" target=\"_blank\" rel=\"noreferrer noopener\">40889076<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41413758\/\" target=\"_blank\" rel=\"noreferrer noopener\">41413758<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40344012\/\" target=\"_blank\" rel=\"noreferrer noopener\">40344012<\/a>).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Praxiom Life is built on a simple idea: biological age is measurable, modifiable, and shows up early in the mouth, the blood, and daily function\u2014not just in how many birthdays you have had. Our Bio\u2011Age engine translates cutting\u2011edge biomarker and&nbsp;&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-36","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Science &amp; Research - Praxiom Life 2.0<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/praxiom.life\/?page_id=36\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science &amp; Research - Praxiom Life 2.0\" \/>\n<meta property=\"og:description\" content=\"Praxiom Life is built on a simple idea: biological age is measurable, modifiable, and shows up early in the mouth, the blood, and daily function\u2014not just in how many birthdays you have had. 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